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Løchen ML (1988) The Tromsö Heart Study: coronary risk factor levels in treated and untreated hypertensives. Kostner GM, Krempler F (1992) Lipoprotein (a). Kasiske BL, O'Donnell MP, Cowardin W, Keane WF (1990) Lipids and the kidney.
Low density lipoprotein iso#
Iso H, Jacobs DR, Wentworth D, Neaton JD, Cohen JD, for the MRFIT Research Group (1989) Serum cholesterol levels and six-year mortality from stroke in 350 977 men screened for the multiple risk factor intervention trial. Hjermann I, Helgeland A, Holme I, Lund-Larsen PG, Leren, P (1978) The association between blood pressure and serum cholesterol in healthy men: the Oslo study. Heinrich J, Sandkamp M, Kokott R, Schulte H, Assmann G (1991) Relationship of lipoprotein (a) to variables of coagulation and fibrinolysis in a healthy population. Hagerup LM (1973) Coronary heart disease risk factors in men and women chap 6, arterial blood pressure. In: Keane WF, Stein JH (eds) Lipids and renal disease, contemporary issues in nephrology. Am J Med 76 :94–96ĭiamond JR (1991) The role of cholesterol in glomerular injury. Am J Med 80 :23–32ĭay JL, Metcalfe J, Simpson N, Lowenthal L (1984) Adrenergic mechanisms in the control of plasma lipids in man. Prevalence of high cholesterol levels in hypertensive patients in the Framingham Study. Springer, Berlin Heidelberg New YorkĬastelli WP, Anderson K (1986) A population at risk. Am Heart J 115:1713–1724īortz J (1989) Statistik für Sozialwissenschaftler, 3rd edn. Atherosclerosis 62:249–257Īssmann G, Schulte H (1988) The Prospective Cardiovascular Münster (PROCAM) study: prevalence of hyperlipidemia in persons with hypertension and/or diabetes mellitus and the relationship to coronary heart disease. Our data suggest different metabolic and pathophysiological mechanisms of the risk factors, IDL, LDL, and Lp(a).Īrmstrong VW, Cremer P, Eberle E, Manke A, Schulze F, Wieland H, Krenzer H, Seidel D (1986) The association between serum Lp(a) concentrations and angiographically assessed coronary atherosclerosis-dependence on serum LDL-levels. Although IDL and Lp(a) are considered lipoprotein risk factors for atherosclerosis, levels of Lp(a), unlike IDL, are not related to blood pressure, body weight, or age. However, levels of Lp(a) correlated neither with systolic or diastolic blood pressure nor with lipoprotein cholesterol, body weight, or age. IDL cholesterol and apo B, the main protein component of IDL and LDL correlated with blood pressure. To this end blood pressure was measured several times in each individual, and lipids, lipoprotein-cholesterol, apolipoprotein B (apo B), and Lp(a) were determined in fasting serum. In the present study we investigated 200 male employees (mean age 26☗ years) to determine whether the relationship of IDL and Lp(a) to systemic blood pressure is similar to the reported correlations between total and LDL cholesterol and systemic blood pressure. Elevated levels of intermediate-density lipoproteins (IDL) and low-density lipoproteins (LDL) were shown to be atherogenic, and LDL, comprising the major cholesterol-carrying fraction in human plasma, are structurally related to lipoprotein (a), a further risk factor for atherosclerosis. Although LDL-C levels showed a positive correlation with TG levels, the LDL-C(F) levels tended to show a greater divergence from LDL-C(D) levels than that shown by LDL-C(M) with changes in TG levels.Ĭonclusion : We for the first time demonstrated a more useful measurement of LDL-C levels estimated by Martin's method than that estimated by the Friedewald equation in Japanese patients with DM.Both hypercholesterolemia and hypertension are risk factors for atherosclerotic vascular disease, and elevated cholesterol levels occur more frequently than expected in patients with hypertension. We further analyzed the effect of serum triglyceride (TG) concentrations on the accuracy of LDL-C(F) and LDL-C(M). Results : On linear regression analysis, LDL-C(M) showed a stronger correlation than that shown by LDL-C(F) ( R=0.979 vs. Methods : Both LDL-C(M) and LDL-C(F) levels were compared against LDL-C(D) measured by selective solubilization method in 1,828 Japanese patients with type 2 DM. The purpose of this study was to validate the LDL-C(M) estimates in Japanese population with type 2 DM by comparing with LDL-C(F) and directly measured LDL-C. The validity of LDL-C(M) in different races and patients with diabetes mellitus (DM) has not been elucidated. was reported to be more accurate than the Friedewald formula in subjects in the United States. A novel method for LDL-C estimation recently proposed by Martin et al.
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Aim : Low-density lipoprotein cholesterol (LDL-C) is routinely estimated using the Friedewald equation.